Perennial herbs or soft shrublets. Leaves opposite. Inflorescences lax terminal or axillary racemes. Flowers in 2-6-flowered whorls; bracts persistent. Calyx 5-toothed, 2-lipped, accrescent; upper tooth largest, ovate, erect; 4 lower teeth equal, horizontal, lanceolate-triangular or subulate. Corolla ± equally 4-lobed; lobes flat. Stamens 4, included in corolla tube. Nutlets subcircular or oblong.
Endostemon is a genus of plants in the Lamiaceae, first described in 1910. It is native primarily to eastern Africa, with some species in central and southern Africa, the Arabian Peninsula, Madagascar, and the Indian Subcontinent.