In vitro alpha-Glucosidase Inhibitory Potential and Antioxidant Activity of Selected Lamiaceae Species Inhabited in Korean Penninsula

Publication Type:Journal Article
Year of Publication:2009
Authors:D. - S. Kim, Kwon, H. Jeong, Jang, H. - D., Kwon, Y. - I.
Journal:Food Sci Biotechnol
Date Published:Jan
Keywords:Antioxidant, Assay, Cancer, Capacity, Disease, Extracts, Fruit, Glucosidase Inhibitor, Lamiaceae, Non-Insulin Dependent Diabetes Mellitus, Oxygen Radical Absorbance Capacity, Phenolic-Compounds, Plasma, Risk, Vegetables

In the current study, inhibitory activity of 8 selected Korean edible plants of Lamiaceae family against alpha-glucosidases, prepared from rat small intestine acetone powder was evaluated. Total flavonoids and oxygen radical absorbance capacity (ORAC) were also investigated. Methyl alcohol extracts of Scutellaria indica (SI) had the highest alpha-glucosidase inhibitory activity relevant for potentially managing hyperglycemia, followed by Clinopodium gracile (CG) and Thymus quinquecostatus (TQ). These 3 species also showed significant antioxidant activity in ORAC system. The alpha-glucosidase inhibitory activity of the extracts was compared to selected phenolics. Among the standard phenolics tested quercetin which was major flavonoid in the extracts had the highest alpha-glucosidase inhibitory activity. CG, TQ, and SI which had high quercetin content and ORAC values also exhibited significant sucrase inhibitory activity. Results suggested that selected 3 Korean Lamiaceae species have the potential development of effective dietary strategy for postprandial hyperglycemia and oxidative stress-linked diabetes complications.

Scratchpads developed and conceived by (alphabetical): Ed Baker, Katherine Bouton Alice Heaton Dimitris Koureas, Laurence Livermore, Dave Roberts, Simon Rycroft, Ben Scott, Vince Smith