Matrix Metalloproteinase-2 Inhibitors from Clinopodium chinense var. parviflorum

Publication Type:Journal Article
Year of Publication:2009
Authors:T. Murata, Sasaki, K., Sato, K., Yoshizaki, F., Yamada, H., Mutoh, H., Umehara, K., Miyase, T., Warashina, T., Aoshima, H., Tabata, H., Matsubara, K.
Journal:J Nat Prod
Date Published:Jan
Keywords:Acid, Oleanane-Triterpene Saponins

From the aerial parts of Clinopodium chinense var. parviflorum, nine new phenylpropanoids, clinopodic acids A-1 (2-10), were isolated together with a known phenylpropanoid, rosmarinic acid (1). The structures of these new compounds were elucidated on the basis of spectroscopic analysis. Clinopodic acid C (4) showed NIMP-2 inhibitory activity (IC50 3.26 mu M).

Scratchpads developed and conceived by (alphabetical): Ed Baker, Katherine Bouton Alice Heaton Dimitris Koureas, Laurence Livermore, Dave Roberts, Simon Rycroft, Ben Scott, Vince Smith