TY - JOUR T1 - Cytotoxic activities of some Greek Labiatae herbs JF - Phytother Res Y1 - 2003 DO - 10.1002/ptr.1175 A1 - RB Badisa A1 - O Tzakou A1 - M Couladis A1 - E Pilarinou SP - 472–476 KW - Brine Shrimps KW - Caco-2 KW - Cytotoxic Activities KW - Diterpenoids KW - Germander KW - Hepatotoxicity KW - Hepg2 KW - Labiatae Species KW - Mcf-7 KW - Medicine KW - Mice KW - Rat Hepatocytes AB - Nineteen methanolic crude plant extracts of Labiatae family, collected in Greece from different locations, were evaluated for cytotoxic activity against brine shrimps and three human cancer cell lines along with a normal mouse cells as a control cell line. In the brine shrimp lethality test, Mentha pulegium was the only sample found to be active with an LC50 value 347.3 mug/ml, while all remaining samples had LC50 values greater than 1000 mug/ml. In case of Caco-2 and HepG2 cell lines, only one sample, namely Thymus parnassicus Halacsy, was active with LC50 values 44.6 and 50.3 mug/ml respectively, while against MCF-7 cell line, two samples, namely, Clinopodium vulgare L. (LC50: 60.4 mug/ml), and Thymus parnassicus Halacsy (LC50: 54.7 mug/ml), were found active. Copyright (C) 2003 John Wiley Sons, Ltd. VL - 17 UR - http://www3.interscience.wiley.com/journal/104529905/abstract ER - TY - JOUR T1 - Study of the oleanolic and ursolic acid contents of some species of the Lamiaceae JF - Biochem Syst Ecol Y1 - 2006 DO - 10.1016/j.bse.2005.12.004 A1 - G Janicsak A1 - K Veres A1 - AZ Kakasy A1 - I Mathe SP - 392–396 KW - Chemotaxonomy KW - Constituents KW - Diterpenoids KW - Gas Chromatography KW - Herb KW - Labiatae KW - Lamiaceae KW - Mice KW - Oleanolic Acid KW - Pentacyclic Triterpenes KW - Salvia-Officinalis KW - Subfamily Lamioideae KW - Subfamily Nepetoideae KW - Triterpenoids KW - Ursolic Acid AB - The oleanolic and ursolic acid contents from 88 taxa. of Lamiaceae (19 genera, 66 species, 8 subspecies, 9 varieties and 5 hybrids) were investigated using gas chromatography. Both triterpenoid acids were present in all of the investigated taxa, but the plants belonging in the subfamily Nepetoideae produced significantly higher amounts than those in the subfamily Lamioideae. The oleanolic acid content ranged from traces to 1.840% dry weight, and that of ursolic acid from traces to 4.019% dry weight. (c) 2006 Elsevier Ltd. All rights reserved. VL - 34 UR - http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T4R-4JCBPHY-1&_user=2139813&_rdoc=1&_fmt=&_orig=search&_sort=d&_docanchor=&view=c&_acct=C000054276&_version=1&_urlVersion=0&_userid=2139813&md5=0fa9d49fb0d0eed1c4653613967dc834 ER -