@article {Dzhambazov:2002p1174,
	title = {In vitro screening for antitumour activity of Clinopodium vulgare L. (Lamiaceae) extracts},
	journal = {Biol Pharm Bull},
	volume = {25},
	number = {4},
	year = {2002},
	month = {Jan},
	pages = {499{\textendash}504},
	abstract = {Aqueous extract of Clinopodium vulgare L. showed strong antitumour activity when tested in vitro on A2058 (human metastatic melanoma), HEp-2 (epidermoid carcinoma, larynx, human) and L5178Y (mouse lymphoma) cell lines-6 h after treatment disintegration of the nuclei and cell lysis started. Applied at a concentration of 80 mug/ml it reduced the cell survival to 1.0, 5.6 and 6.6\%, respectively. The concentrations of aqueous extract inhibiting the growth of A2058, HEp-2 and L5178Y cells by 50\% (IC50 values) were calculated to be 20, 10 and 17.8 mug/ml respectively. Two groups of active substances were detected: the first one, probably combining glycosides, influenced adhesion, while the second one caused massive cell vacuolisation. The chloroform extract, which contained ursolic acid and gentriacontan had also cytotoxic, however a little bit weaker effect. All changes observed were irreversible.},
	keywords = {Antitumour Activity, Chinensis, Clinopodium Vulgare L., Hela-Cells, Induced Phospholipid-Metabolism, Inhibitory Activity, Oleanane-Triterpene Saponins, Plant, Plant Extract, Steroidal Saponins, Ursolic Acid},
	url = {http://apps.isiknowledge.com/InboundService.do?product=WOS\&action=retrieve\&SrcApp=Papers\&UT=000174690200019\&SID=2AFL5dnj5MCc8JPedL5\&SrcAuth=mekentosj\&mode=FullRecord\&customersID=mekentosj\&DestFail=http\%253A\%252F\%252Faccess.isiproducts.com\%252Fcustom_image},
	author = {B Dzhambazov and S Daskalova and A Monteva and N Popov}
}
@article {Wei:2004p1170,
	title = {Chemical constituents from Clinopodium urticifolium},
	journal = {J Chin Chem Soc-Taip},
	volume = {51},
	number = {5A},
	year = {2004},
	month = {Jan},
	pages = {1043{\textendash}1049},
	abstract = {Six new triterpene saponins and a new lignan have been isolated from the n-BuOH and EtOAc solubles of the MeOH extracts of the whole plant of Clinopodium urticifolium. The structures of the new secondary metabolites, named clinopodiside I-V (6,1, 2,3, 4), clinoposaponin Ga (5) and R-(Z)-rosmarinic acid B (7), were deduced from the spectroscopic data (1D, 2D-NMR, FAB-MS, HRESI-MS, EI-MS) and by chemical transformation studies.},
	keywords = {Bupleurum-Falcatum L, Clinopodium Urticifolium, Flavonoids, Herb, Oleanane-Triterpene Saponins, Oleanane-Triterpene Saponins Lignan, Roots, Saikogenin, Saikosasponin-Type Saponins, Sapogenin},
	url = {http://apps.isiknowledge.com/InboundService.do?product=WOS\&action=retrieve\&SrcApp=Papers\&UT=000224625900024\&SID=2AFL5dnj5MCc8JPedL5\&SrcAuth=mekentosj\&mode=FullRecord\&customersID=mekentosj\&DestFail=http\%253A\%252F\%252Faccess.isiproducts.com\%252Fcustom_image},
	author = {XM Wei and JK Cheng and DL Cheng and LM Gao}
}
@article {Murata:2009p1161,
	title = {Matrix Metalloproteinase-2 Inhibitors from Clinopodium chinense var. parviflorum},
	journal = {J Nat Prod},
	volume = {72},
	number = {8},
	year = {2009},
	month = {Jan},
	pages = {1379{\textendash}1384},
	abstract = {From the aerial parts of Clinopodium chinense var. parviflorum, nine new phenylpropanoids, clinopodic acids A-1 (2-10), were isolated together with a known phenylpropanoid, rosmarinic acid (1). The structures of these new compounds were elucidated on the basis of spectroscopic analysis. Clinopodic acid C (4) showed NIMP-2 inhibitory activity (IC50 3.26 mu M).},
	keywords = {Acid, Oleanane-Triterpene Saponins},
	doi = {10.1021/np800781t},
	url = {http://pubs.acs.org/doi/abs/10.1021/np800781t},
	author = {Toshihiro Murata and Kenroh Sasaki and Kumiko Sato and Fumihiko Yoshizaki and Haruna Yamada and Hiromichi Mutoh and Kaoru Umehara and Toshio Miyase and Tsutomu Warashina and Hiroaki Aoshima and Homare Tabata and Kouichi Matsubara}
}
