@article {Dzhambazov:2002p1174,
	title = {In vitro screening for antitumour activity of Clinopodium vulgare L. (Lamiaceae) extracts},
	journal = {Biol Pharm Bull},
	volume = {25},
	number = {4},
	year = {2002},
	month = {Jan},
	pages = {499{\textendash}504},
	abstract = {Aqueous extract of Clinopodium vulgare L. showed strong antitumour activity when tested in vitro on A2058 (human metastatic melanoma), HEp-2 (epidermoid carcinoma, larynx, human) and L5178Y (mouse lymphoma) cell lines-6 h after treatment disintegration of the nuclei and cell lysis started. Applied at a concentration of 80 mug/ml it reduced the cell survival to 1.0, 5.6 and 6.6\%, respectively. The concentrations of aqueous extract inhibiting the growth of A2058, HEp-2 and L5178Y cells by 50\% (IC50 values) were calculated to be 20, 10 and 17.8 mug/ml respectively. Two groups of active substances were detected: the first one, probably combining glycosides, influenced adhesion, while the second one caused massive cell vacuolisation. The chloroform extract, which contained ursolic acid and gentriacontan had also cytotoxic, however a little bit weaker effect. All changes observed were irreversible.},
	keywords = {Antitumour Activity, Chinensis, Clinopodium Vulgare L., Hela-Cells, Induced Phospholipid-Metabolism, Inhibitory Activity, Oleanane-Triterpene Saponins, Plant, Plant Extract, Steroidal Saponins, Ursolic Acid},
	url = {http://apps.isiknowledge.com/InboundService.do?product=WOS\&action=retrieve\&SrcApp=Papers\&UT=000174690200019\&SID=2AFL5dnj5MCc8JPedL5\&SrcAuth=mekentosj\&mode=FullRecord\&customersID=mekentosj\&DestFail=http\%253A\%252F\%252Faccess.isiproducts.com\%252Fcustom_image},
	author = {B Dzhambazov and S Daskalova and A Monteva and N Popov}
}
