|Publication Type:||Journal Article|
|Year of Publication:||2003|
|Authors:||Badisa, RB, Tzakou, O, Couladis, M, Pilarinou, E|
|Keywords:||Brine Shrimps, Caco-2, Cytotoxic Activities, Diterpenoids, Germander, Hepatotoxicity, Hepg2, Labiatae Species, Mcf-7, Medicine, Mice, Rat Hepatocytes|
Nineteen methanolic crude plant extracts of Labiatae family, collected in Greece from different locations, were evaluated for cytotoxic activity against brine shrimps and three human cancer cell lines along with a normal mouse cells as a control cell line. In the brine shrimp lethality test, Mentha pulegium was the only sample found to be active with an LC50 value 347.3 mug/ml, while all remaining samples had LC50 values greater than 1000 mug/ml. In case of Caco-2 and HepG2 cell lines, only one sample, namely Thymus parnassicus Halacsy, was active with LC50 values 44.6 and 50.3 mug/ml respectively, while against MCF-7 cell line, two samples, namely, Clinopodium vulgare L. (LC50: 60.4 mug/ml), and Thymus parnassicus Halacsy (LC50: 54.7 mug/ml), were found active. Copyright (C) 2003 John Wiley Sons, Ltd.