Cytotoxic activities of some Greek Labiatae herbs

Publication Type:Journal Article
Year of Publication:2003
Authors:Badisa, RB, Tzakou, O, Couladis, M, Pilarinou, E
Journal:Phytother Res
Volume:17
Pagination:472–476
Date Published:Jan
Keywords:Brine Shrimps, Caco-2, Cytotoxic Activities, Diterpenoids, Germander, Hepatotoxicity, Hepg2, Labiatae Species, Mcf-7, Medicine, Mice, Rat Hepatocytes
Abstract:

Nineteen methanolic crude plant extracts of Labiatae family, collected in Greece from different locations, were evaluated for cytotoxic activity against brine shrimps and three human cancer cell lines along with a normal mouse cells as a control cell line. In the brine shrimp lethality test, Mentha pulegium was the only sample found to be active with an LC50 value 347.3 mug/ml, while all remaining samples had LC50 values greater than 1000 mug/ml. In case of Caco-2 and HepG2 cell lines, only one sample, namely Thymus parnassicus Halacsy, was active with LC50 values 44.6 and 50.3 mug/ml respectively, while against MCF-7 cell line, two samples, namely, Clinopodium vulgare L. (LC50: 60.4 mug/ml), and Thymus parnassicus Halacsy (LC50: 54.7 mug/ml), were found active. Copyright (C) 2003 John Wiley Sons, Ltd.

URL:http://www3.interscience.wiley.com/journal/104529905/abstract
DOI:10.1002/ptr.1175
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